Oral lesions of systemic lupus erythematosus: A collaborative Latin American study.

BACKGROUND: Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that may affect the oral mucosa. The variable spectrum of oral lesions observed in SLE can pose challenges in diagnosis, particularly when the lesions occur in isolation. The aim of this study was to describe the oral lesions occurring in patients with SLE from Latin America. METHODS: This collaborative record-based study involving 11 oral and maxillofacial pathology and medicine services across Venezuela, Argentina, Chile, Brazil, and Mexico describes the clinicopathological profile of SLE-related oral lesions. RESULTS: Seventy patients with SLE and oral lesions were included in the study. The majority were females (75.7%; female/male ratio: 3.1:1) and white (62.1%), with a mean age of 38.4 years (range: 11-77 years). The most common site of oral lesions was the hard/soft palate (32.0%). Clinically, oral lesions predominantly presented as ulcers (26.6%), erosions (26.6%), and white lesions (23.4%). Isolated oral lesions occurred in 65.2% of individuals, while cutaneous manifestations occurred in 80.3%. The main clinical diagnostic hypothesis in 71.4% of cases was an immune-mediated disease. Oral biopsies followed by histopathological analysis were performed in 50 cases. CONCLUSION: Oral lesions of SLE exhibit a variety of clinical and histopathological features. A key point in diagnosis is that unusual oral changes without an obvious local cause may indicate a possible systemic condition presenting with oral lesions. A multidisciplinary approach, which includes regular oral examination, is warranted to identify oral lesions and provide treatment.

Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study.

OBJECTIVE: To determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America. METHODS: A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential-OSCC versus OSCC-de novo (OSCC-dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t-test, and qualitative variables with chi-square. RESULTS: In total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC-dn, while s-OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD. CONCLUSIONS: In Latin America, OSCC-dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.

Schwanoma palatino en paciente pediátrico de 12 años: una rara presentación clínica

El schwanoma es un tumor neural que se origina en las células de Schwann presentes en la vaina nerviosa cuya localización más frecuente a nivel oral es el dorso de lengua, siendo mucho más frecuente en adultos. En población pediátrica la presentación es muy rara siendo lengua su ubicación más frecuente, mientras que a nivel palatino solo se conocen 11 reportes en menores de 16 años. El objetivo de este reporte es presentar un caso clínico inusual de schwanoma palatino en un niño chileno de 12 años de edad, quien fue derivado con diagnóstico clínico presuntivo de carcinoma mucoepidermoide. El caso se complementó con radiografía panorámica, Conebeam, y luego biopsia incisional. Finalmente, se diagnosticó schwanoma palatino variedad sólida. Es importante considerar al schwanoma como diagnóstico diferencial en casos de tumores palatinos, en especial en casos pediátricos ya que se pueden presentar similares características clínicas a tumores de glándula salival.

The Schwannoma or neurilemmoma tumor originates from Schwann cells present in nerve sheaths. At oral level, its most frequent location is at the back of the tongue, being much more frequent in adults. In the pediatric population, this occurrence is rare and most frequently found in the tongue. At palatal level, only 11 reports are known in children under 16 years of age. The aim of this report is to present an unusual clinical case of palatal schwannoma in a 12-year-old Chilean boy, referred with a clinical diagnosis of mucoepidermoid carcinoma. The case was complemented with panoramic radiography and Cone beam, for its subsequent incisional biopsy. Finally, a solid palatal schwannoma was diagnosed. It is important to consider schwannoma as a differential diagnosis in cases of palatal tumors, especially in pediatric cases, since they can present similar clinical characteristics to salivary gland tumors.

Oral squamous cell carcinoma in coca chewers from a north region of Argentina: A case series and review of literature.

Chewing coca leaves is a habit still practiced in Bolivia, Peru and Argentina. There is scarce evidence in the relationship between this habit and development of oral squamous cell carcinoma (OSCC), some authors have found oral epithelial changes in coca chewers. This study aimed to present a case series of patients with a coca chewing habit that developed OSCC, in the absence of risk factors for oral cancer. Patients were evaluated in Hospital Señor del Milagro, Salta, Argentina. None of them had a relevant morbid history and presented intraoral tumors, with an ulcerated surface on the gingivobuccal complex. Coca chewing habit was recorded in all cases. Present cases could start discussions and new lines of researches focusing on the habit of coca leaves chewing as a risk factor for OSCC. It would be very useful to know the underlying mechanisms between this habit and a possible role in oral carcinogenesis.

Candidiasis of the tongue in cannabis users: a report of 2 cases.

Cannabis, a psychoactive drug widely used for medicinal, recreational, and religious purposes, can have detrimental effects on several body systems, including the respiratory, cardiovascular, and central nervous systems. The use of cannabis in cigarette form can produce a series of oral alterations, including periodontitis, caries, xerostomia, a decreased salivary pH, and an increase in the density of Candida albicans. However, the occurrence of oral candidal lesions related to cannabis use is little reported in the literature. This article reports 2 cases of oral candidiasis associated with cannabis use. The adult male patients, both of whom were systemically healthy, had white and red spots consistent with oral candidiasis on the dorsal surface of the tongue. One of the patients also had a red lesion on an area of the hard palate that was in contact with the affected area of the tongue. Neither patient was currently undergoing antibiotic or corticosteroid treatment, and both reported frequent smoking of cannabis. One patient was initially treated with an oral suspension of nystatin without clinical improvement. Miconazole gel therapy was then prescribed, and clinical improvement was observed after 2 weeks. The patient did not stop smoking cannabis, and a recurrence of oral candidiasis was observed 6 months posttreatment. Treatment with miconazole gel was repeated, resulting in resolution of the infection. The second patient declined treatment. The reported cases demonstrate that, although it is infrequently reported, oral candidiasis may occur in cannabis smokers.

People living with HIV/AIDS: appraisal on dental care in Salta, Argentina / Personas que viven con VIH-SIDA: apreciación sobre la atención odontológica en Salta, Argentina

Abstract Introduction: many patients living with HIV-AIDS (PLHIV) feel discriminated due to their disease, both socially and in health centers, including dental care. However, no current studies are available in Argentina regarding the preferences of these patients when visiting a dentist, the places where they prefer to be treated, or if they disclose their HIV(+) status, among other situations. Objective: to determine PLHIV's appraisal on dental care in Salta, Argentina. Methods: descriptive, cross-sectional study. The study population were subjects who attended the HIV/STIs Program in the Salta Province in the period June-September 2015. Sociodemographic data, underlying disease, and dental care were collected in a survey created for this purpose. Results: 200 PLHIV were surveyed. 54% were male aged 37 years in average (IQR 29.2-45), with a median period of disease evolution of 78 months (IQR 30-126). 78% of respondents consulted a dentist in the last two years and 60% did so in public institutions. 70% perceived that their dentist has some knowledge on HIV. 50.5% disclosed their serological status to the treating professional. 87% reported that there were no prejudices during the service provided. Of the 49.6% who did not disclose their diagnosis, 55% claimed fear of discrimination. Conclusion: although PLHIV's appraisal of dental care was positive, with no prejudices in most cases, fear of discrimination is the main reason for not informing the dentist of their diagnosis. Interdisciplinary work would help PLHIV in comprehensive care, thus avoiding one more reason for non-adherence to treatment.

Resumen Introducción: muchos pacientes que viven con VIH-SIDA (PVVS) se sienten discriminados por su enfermedad, tanto en el ámbito social como en establecimientos de salud, incluyendo la atención odontológica. Sin embargo, en la actualidad no existen en Argentina estudios que permitan establecer las preferencias de estos pacientes al momento de acudir a un odontólogo, como el lugar donde prefieren ser atendidos, o si mencionan su condición de VIH(+), entre otros aspectos. Objetivo: determinar la apreciación de las PVVS sobre la atención odontológica en Salta, Argentina. Métodos: estudio descriptivo, de corte transversal. La población estudiada fueron sujetos que acudieron al Programa Provincial VIH/ITS de Salta entre junio y septiembre de 2015. Se recolectaron datos sociodemográficos, enfermedad de base y atención odontológica, en una encuesta diseñada para tal fin. Resultados: se encuestaron 200 PVVS: 54% de género masculino, con una edad promedio de 37 años (RIC 29,2-45), tiempo mediano de evolución de la enfermedad de 78 meses (RIC 30-126). Un 78% consultó al odontólogo en los últimos dos años y 60% utilizó establecimientos públicos como lugar de atención. Un 70% percibió que el odontólogo tiene conocimientos sobre VIH. El 50,5% manifestó su estado serológico al profesional tratante. 87% refirió que recibieron atención odontológica sin ningún prejuicio. Del 49,6% que no dio a conocer su diagnóstico, el 55% adujo miedo a la discriminación. Conclusión: si bien la apreciación de las PVVS sobre la atención odontológica fue positiva, mayoritariamente sin prejuicios, el miedo a la discriminación es la principal causa para no dar a conocer el diagnóstico al odontólogo. El trabajo interdisciplinario ayudaría a las PVVS en la atención integral, evitando ser un motivo más para la falta de adherencia al tratamiento.

Leishmaniasis mucocutánea con manifestacion oral: reporte de un caso / Mucocutaneous leishmaniasis with oral manifestation: case report

La Leishmaniasis es un grupo de enfermedades transmitidas por vectores y causada por la Leishmania, un parásito intracelular, que se presenta de preferencia en regiones tropicales y subtropicales. Se manifiesta mediante un amplio rango de formas clínicas como la cutánea, mucocutánea, y visceral, dependiendo de la especie y respuesta inmunológica del paciente. Se presenta el caso de un hombre de 35 años que acudió derivado a Unidad de Estomatología del Hospital Señor del Milagro, Salta, Argentina, presentando en la cavidad oral lesión, granulomatosa, ulcerada, dolorosa a la palpación, única, en paladar blando, de tres meses de evolución. Se realizaron estudios serológicos, parasitológicos y PCR. Los ELISAs lisados, PCRs y cultivos de materiales de lesiones fueron positivos, confirmando diagnóstico de leishmaniasis mucocutánea. El paciente fue derivado al Servicio de Dermatología donde recibió tratamiento con Antimoniato de Meglumina, con repuesta clínica favorable. El conocimiento de las manifestaciones orales puede llevar al diagnóstico clínico de leishmaniasis mucocutánea por parte del odontólogo, pudiendo entregar un tratamiento oportuno y a la vez ayudar al paciente, evitando complicaciones de esta enfermedad.

Leishmaniasis is a group of vector-borne diseases caused by Leishmania, an intracellular parasite, which occurs preferentially in tropical and subtropical regions. It manifests itself through a wide range of clinical forms such as cutaneous, mucocutaneous, and visceral, depending on the species and the patient's immune response. We present a case of a 35-year-old man who was referred to the Stomatology Unit of the Señor del Milagro Hospital, Salta, Argentina, presenting in the oral cavity lesion, granulomatous, ulcerated, painful on palpation, unique, soft palate with three months of evolution. Serological, parasitological and PCR studies were performed. Lysed ELISAs, PCRs and cultures of lesion materials were positive, confirming diagnosis of mucocutaneous leishmaniasis. The patient was referred to the Dermatology Service where he received treatment with Meglumine Antimony, with favorable clinical response. The knowledge of the oral manifestations can lead to the clinical diagnosis of mucocutaneous leishmaniasis by the dentist, being able to provide timely treatment and at the same time help the patient, avoiding complications of this disease.

Granuloma piógeno de presentación inusual: Reporte de caso

El granuloma piógeno se considera una lesión reactiva, que surge en respuesta a variados estímulos. Su etiología más común es el trauma y se asocia a higiene oral deficiente. De tamaño variable, la mayoría de los casos asintomáticos y es común su desarrollo en encía. Principalmente se asocia a mujeres jóvenes, en la segunda década de vida, posiblemente debido a un efecto vascular mediado por cambios hormonales. Se presenta el caso de una paciente de 22 años, que presenta una lesión de 10 años de evolución, dolorosa, en encía en relación con los dientes 1.1 a 1.4, la cual clínicamente era compatible con fibroma. Se dispuso una biopsia excisional, y el diagnóstico histológico fue un granuloma piógeno fibrosado. Al control postquirúrgico, se apreció cicatrización excelente, asintomático y sin signos de recidiva posterior a un año de control. El diagnóstico definitivo fue dado mediante estudio histopatológico, lo que indica la vital importancia de este tipo de exámenes cada vez que se realiza la extirpación de alguna lesión. El granuloma piógeno no se puede considerar como una neoplasia verdadera, sino como una lesión reactiva que va modificándose con el tiempo y va variando su estructura.

Pyogenic granuloma is considered as a reactive lesion, which is produced as a response to various stimuli. Its most common cause is trauma which is associated with poor oral hygiene. Resizable, most asymptomatic cases and are common developed in gum. It is mainly associated to young women, during the second decade of life, possibly due to a vascular effect mediated by hormonal changes. A 22-year-patient is presented, with an injury of 10 years of evolution, painful, in gum relative to the teeth 1.1 to 1.4, which was clinically suitable to fibroma. An excisional biopsy was indicated, with the histological diagnosis, and it resulted in a fibrotic pyogenic granuloma. In the post surgical control, wound healing was excellent, asymptomatic and without signs of recurrence after one year of monitoring. The definitive diagnosis was given by a histopathological study, which indicated the vital importance of these tests each time a removal of injury is made. Pyogenic granuloma can not be considered as a true neoplasm but as a reactive lesion, that evolves over time and is changing its structure.

Esclerosis Tuberosa: caso clínico, manifestaciones bucales y revisión de la literatura / Tuberous sclerosis: clinical case, oral manifestations and review of the literature

La esclerosis tuberosa (TS) es un síndrome con base genética que produce manifestaciones generales, intraorales y faciales. Se presenta un caso clínico y las bases genéticas etiológicas de la misma, en función de una revición bibliográfica. El odontólogo debe conocer la TS, para integrar y asesorar al equipo de salud en las manifestaciones bucofaciales de estos enfermos